高强度聚焦超声脾消融联合药物治疗化疗相关血小板减少症的疗效及安全性分析

任捷; Zhui Ke; 高洁; 卢静怡; 邱裕友; 罗蓓; 邹文杰; 袁敏; 许青

doi:10.62177/fcdt.v2i3.1386

Authors

任捷同济大学附属第十人民医院
Zhui Ke Tongji University Affiliated Shanghai Tenth People’s Hospital
高洁同济大学附属第十人民医院
卢静怡同济大学附属第十人民医院
邱裕友同济大学附属第十人民医院
罗蓓同济大学附属第十人民医院
邹文杰同济大学附属东方医院
袁敏同济大学附属第十人民医院
许青同济大学附属第十人民医院

DOI:

https://doi.org/10.62177/fcdt.v2i3.1386

Keywords:

化疗相关血小板减少症（CIT）, 高强度聚焦超声（HIFU）, 联合治疗, 脾消融

Abstract

目的：探讨高强度聚焦超声（HIFU）脾消融联合药物治疗化疗诱导性血小板减少症（CIT）的疗效与安全性。方法：回顾性分析2017—2021年我院54例CIT患者临床资料，根据治疗方式分为HIFU组、药物组及HIFU联合药物组。比较各组治疗前及治疗后7 d、14 d、30 d、60 d血小板计数变化，并观察影像学改变及不良反应情况。结果：HIFU联合药物组治疗后7 d血小板计数即明显升高，增长率为60.79%，显著高于单纯药物组（P＜0.001）。14 d时联合组仍维持较高水平。30 d后两组差异无统计学意义。单纯HIFU组血小板计数未见明显升高。影像学显示HIFU消融区呈无灌注改变。治疗前后血常规、凝血功能及肝功能指标差异均无统计学意义（P＞0.05）。联合组87.5%患者按期完成下一周期化疗，高于药物组的68.2%。结论：HIFU脾消融联合药物治疗可加快CIT患者血小板恢复，提高化疗完成率，且安全性良好。

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