Metabolite-Chromatin Interaction Network Drives Kidney Regeneration: The Coordinated Regulation of Succinate/H3K9ac and α-KG/TET Demethylation

Peng Lu; Lei  Zhang; Jingjing Fan; Jin Xing; Li Xu; Yan Sun

doi:10.62177/apjcmr.v1i2.316

Authors

Peng Lu Department of Clinical Laboratory, Cangzhou Central Hospital
Lei Zhang Department of Clinical Laboratory, Cangzhou Central Hospital
Jingjing Fan Department of Emergency ICU, Cangzhou Central Hospital
Jin Xing Department of Nephrology, Cangzhou Central Hospital
Li Xu Department of Clinical Laboratory, Cangzhou Central Hospital
Yan Sun Department of Clinical Laboratory, Cangzhou Central Hospital

DOI:

https://doi.org/10.62177/apjcmr.v1i2.316

Keywords:

Metabolite-Epigenetic Interaction, Succinate/H3K9ac, α-KG/TET Enzymes, Renal Stem Cells

Abstract

As the "fourth messenger" of epigenetic regulation, metabolites playa spatiotemporally specific regulatory role in kidney regeneration by dynamically reshaping the state of chromatin modifications. This review systematically expounds the coordinated mechanism of the dual axes of succinate/H3K9ac and α-ketoglutarate (α-KG)/TET enzymes: Succinate activates regeneration-related genes by regulating histone acetylation (H3K9ac), while α-KG relieves the epigenetic repression of the Wnt pathway through TET-mediated DNA demethylation. The dynamic balance between the two maintains epigenetic plasticity. Multi-omics integration strategies (such as Gaussian graphical models and deep learning frameworks) and single-cell epigenetic tracking technologies (such as spatial metabolomics) have revealed the regulation of metabolite gradients on cellular heterogeneity and the immune microenvironment. The coordinated application of metabolite precursor supplementation (such as NAD precursors) and dynamic monitoring systems (such as isotope tracing and artificial intelligence models) has promoted the shift of metabolic medicine from the "static replacement" paradigm to the "dynamic reshaping" paradigm. However, technical bottlenecks (such as insufficient multimodal integration) and clinical translation pitfalls (such as challenges in standardized production) still need to be overcome. In the future, through the development of "metabolism-immunity" co-regulatory strategies and intelligent closed-loop systems, it is expected to achieve precise interventions for kidney regeneration and disease treatment.

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