The Impact and Significance of Prenatal Blood Analysis on Postpartum Hemorrhage in Advanced-Age Primiparous Women

Xiaosu Huang; Chunhong Pan; Yuhua Wu; Zhichun Wei

doi:10.62177/apjcmr.v2i3.1420

Authors

Xiaosu Huang Baise People’s Hospital
Chunhong Pan Xi’an Polytechnic University
Yuhua Wu Baise People’s Hospital
Zhichun Wei Baise People’s Hospital

DOI:

https://doi.org/10.62177/apjcmr.v2i3.1420

Keywords:

Advanced Maternal Age, FIB, D-D, Hb, PLT, Postpartum Hemorrhage, Multivariate Logistic Regression Analysis, ROC Curve

Abstract

Objective: To investigate the correlation between prenatal plasma fibrinogen, D-dimer, hemoglobin, and platelet levels and postpartum hemorrhage in primiparous women of advanced maternal age. Methods: Fifty elderly primiparous women who delivered without postpartum hemorrhage and 50 who experienced postpartum hemorrhage were assigned to the control and experimental groups, respectively. Five milliliters of fasting venous blood were collected from each woman between 31 and 33 weeks of gestation. FIB, D-dimer, Hb, and PLT levels were measured using a fully automated hematology analyzer. Multivariate logistic regression analysis was performed, and ROC curves were plotted. Results: Compared with the control group, the experimental group showed statistically significant differences in FIB and Hb levels (P < 0.05), and extremely significant differences in PLT levels (P < 0.01). There was no statistically significant difference in D-D levels between the two groups (P > 0.05). FIB and PLT were identified as independent risk factors for postpartum hemorrhage, and both may contribute to the occurrence of postpartum hemorrhage. Conclusion: FIB and PLT showed significant correlations with postpartum hemorrhage, suggesting that FIB and PLT may contribute to the development of postpartum hemorrhage.

Downloads

Download data is not yet available.

References

Xu, L., Bu, F. B., & Geng, G. (2026). The impact of prenatal Hb levels and baseline characteristics on the outcomes and predictive value of transfusion therapy for postpartum hemorrhage. Chinese Journal of Family Planning, 34(1), 120–124.

Moreuil, D. C., Petesch, P. B., Mehic, D., et al. (2024). Pradelivery hemostatic biomarkers in women with non-severe postpartum hemorrhage. Journal of Clinical Medicine, 13(14), 4231.

Duan, X. X., Feng, S. S., & Wang, J. (2025). Predictive value of changes in prenatal serum miR-296 and miR-21 levels for postpartum hemorrhage in women with pregnancy-induced hypertension. Journal of Microcirculation, 35(4), 69–73.

Oyelese, Y. (2024). Imaging of antepartum and postpartum hemorrhage: Contemporary classification of placenta previa. Radiographics, 44(7), e240127.

Dimri, U., Baranwal, A., Roy, B., et al. (2025). Estimation of feto-maternal hemorrhage using flow cytometry in antenatal care patients at a tertiary care hospital in western Maharashtra. Medical Journal of the Armed Forces of India, 81(5), 591–597.

Xie, Y. D., Hong, Y. H., Zeng, S. F., et al. (2025). Correlation between prenatal mitogen-activated protein kinase-related factor expression and postpartum hemorrhage in women undergoing repeat cesarean section, and analysis of the therapeutic efficacy of tranexamic acid. Chinese Journal of Maternal and Child Health, 40(17), 3122–3125.

Raffaelli, R., Pinto, A., Fontana, S., et al. (2025). Hemorrhagic pericardial cyst: Prenatal ultrasound and magnetic resonance imaging with postnatal outcome and literature review. Ultrasound in Obstetrics & Gynecology, 66(5), 671–673.

Cao, X. Y., Li, S. F., & Ren, X. P. (2025). Analysis of the value of prenatal serum TIMP-1, TGF-β1, and thromboelastogram in predicting postpartum hemorrhage in pregnant women with pregnancy-induced hypertension. Chinese Journal of Modern Medicine, 35(13), 18–23.

Xi, X. Y. (2025). The impact of prenatal psychological care on mode of delivery, postpartum hemorrhage, and negative emotions in primiparous women. Contemporary Medical Forum, 23(15), 178–181.

Jiang, H. D., Shen, J. J., Wang, W., et al. (2025). Clinical value of prenatal MRI in assessing placental invasion and postpartum hemorrhage in patients with complete placenta previa. Journal of Molecular Imaging, 48(4), 441–445.

Zhao, R. X., Kang, R., Guo, J. N., et al. (2025). Analysis of the correlation between prenatal MRI and ultrasound features of malignant placenta previa and postpartum hemorrhage. Journal of Translational Medicine, 14(4), 47–52.

Yan, Y. (2025). The application value of prenatal hemoglobin, platelet count, D-dimer, and coagulation panel testing in predicting postpartum hemorrhage in advanced-age pregnant women. Journal of Practical Medical Technology, 32(1), 57–60.

Huang, Y. M. (2024). The role of prenatal standardized enhanced nursing interventions in preventing postpartum hemorrhage in advanced-age pregnant women. Smart Health, 10(33), 170–172, 176.

Wang, P., Yang, L. J., Gao, M., et al. (2024). Anticoagulant function in pregnant women with placenta previa and its relationship with postpartum hemorrhage. Research and Practice in Health Care Medicine, 21(10), 48–54.

Yen, T. V. (2024). Prenatal sonographic diagnosis and postnatal outcomes of fetal intracranial hemorrhage: Two case report. Radiology Case Reports, 19(9), 4066–4072.