Analysis of Risk Factors for Diabetic Retinopathy and the Role and Mechanisms of Melatonin

Xizhi Zhang

doi:10.62177/amit.v2i5.1663

Authors

Xizhi Zhang Coppell High School

DOI:

https://doi.org/10.62177/amit.v2i5.1663

Keywords:

Diabetic Retinopathy, Melatonin, Risk Factors, Analysis

Abstract

Diabetic retinopathy is a common microvascular complication of diabetes and the leading cause of blindness in working-age people. Oxidative damage is an important mechanism leading to diabetic retinopathy, and inflammatory response also plays an important role in its development. Furthermore, one of the hallmarks of diabetic retinopathy is impaired autophagy. Melatonin is a molecule with powerful antioxidant effects. It also has significant anti-inflammatory effects and can inhibit the expression of a variety of inflammatory factors. The eyes are one of the key sites for melatonin secretion, and eye tissue is the main place where melatonin plays its role. Melatonin has been shown to have neuroprotective effects in experimental and clinical models of several eye diseases. Systematic evaluation of risk factors for diabetic retinopathy in patients with diabetes provides a scientific basis for effective clinical prevention and treatment. Relevant studies were summarized on risk factors for patients with diabetes, and literature screening, data extraction, and quality assessment were performed.

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